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In real world GLP-1 populations, especially older adults and Medicare patients with multiple chronic conditions, interpreting lean mass loss is often far more complex than it appears

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In a pharmacological context, it has recently been shown that GIP induces weight loss by stimulating satiety in the hypothalamus, one of the sites of GIPR (27, 41), and chronic stimulus of GIPR in adipocytes desensitizes the receptor, causing antagonism (42)

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